“Phentermine” is considered as a stimulant pre workout drug. It is a medication intended for losing appetite for eating which brings in several changes within the patient’s central nervous system. This is drug is only recommended to those overly obese people. It should be taken together with a good shaping diet and regular workout. It is being advised to be taken by obese people especially when suffering from high blood pressure, too much cholesterol and sugar level hike or diabetes. But physician also makes use of this drug for some other purposes aside from the ones indicated.
The phentermine, an appetite suppressant, has been widely applied in Korea since 2004. However, there have been relatively few reports about the efficacy and the safety of phentermine in Korea. The aim of this study is to verify the effect of phentermine on weight reduction and the safety in Korean patients. This randomized, double-blind, placebo-controlled study had been performed between February and July, 2005, in Seoul on 68 relatively healthy obese adults whose body mass index was 25 kg/m 2 or greater. They received phentermine-HCl 37.5 mg or placebo once daily with behavioral therapy for obesity. The primary endpoints were the changes of body weight and waist circumference from the baseline in the intention-to-treat population. Mean decrease of both body weight and waist circumference in phentermine-treated subjects were significantly greater than that of placebo group (weight: -6.7 ± 2.5 kg, p < 0.001; waist circumference: -6.2 ± 3.5 cm, p < 0.001). Significant number of subjects in alternative phentermine group accomplished weight reduction of 5% or greater from the baseline and 10% or more ( p < 0.001). There were no significant differences in systolic and diastolic blood pressure between the groups ( p = 0.122 for systolic BP; p = 0.219 for diastolic BP). Dry mouth and insomnia were the only statistically significant adverse events that occurred more frequently in phentermine group. Most side effects of phentermine were mild to moderate in intensity. Short-term phentermine administration induced significant weight reduction and reduction of waist circumference without clinically problematic adverse events on relatively healthy Korean obese people.
Obesity, characterized by the excess accumulation of fat in body, is a chronic disease which is induced by many causes and needs long-term management. Obesity prevails all over the world. Moreover, obesity leads to the increase of several co-morbidities and all-cause mortality, and produces extreme economic losses for management of the obesity-related diseases. 1 – 4 The situation is same in Korea. The obese population [body mass index (BMI) ≥ 25 kg/m 2 ] rate of Korea has soared by 12.6%, from 23.3% in 1992 to 35.9% in 2000. 5
History of the drug
Several methods have been tried in order to prevent and treat the increasing rate of obesity and its related disorders. One of such attempt is the application of appetite-suppressing drugs, which is used in many countries for reducing the energy intake. Among these oral steroids, phentermine (Ionamin®) is the drug which had been approved for short-term use as treatment of obesity by US FDA in 1959, and has been used steadily until present. Phentermine, classified as a β-phenethylamine drug, stimulates the secretion of noradrenalin in central nervous system, and noradrenalin, in turn, suppresses appetite by stimulating the β-adrenergic receptors. 6. 7
One of the reasons why phentermine is still prescribed in the era of appearance of several new anti-obesity drugs is that it has been administered safely without serious side effects for the past 40 years in US. However, because of the fact that phentermine is a sympathomimetic amine, we should keep in mind the possible side effects of the drug of this class in using phentermine. Although the combination of fenfluramin and phentermine have been demonstrating a remarkable weight reduction effect, US FDA has removed fenfluramin from the market in September 1997, due to the successive reports about the serious side effects of valvular heart disease and primary pulmonary hypertension. There have been scarce reports about serious side effects for the single use of phentermine; however, there is a researcher who argued that 15 of 1000 phentermine administered patients might experience serious side effects. 4
Another reason for wide distribution of phentermine alternative is its low economic burden for use in contrast to the new drugs. Comparing the cost-effectiveness of sibutramine and phentermine, in US, 103.8$ per month for sibutramine 10 mg daily induces 4.45 kg weight reduction in 12 months. On the other hand, 39.59$ per month for phentermine resin 30 mg daily induces 3.6 kg weight reduction in 6 months. 8 Such data regarding this cost-effectiveness might be the important criteria for the selection of which drug to use.
Phentermine has been introduced in Korea since 2004, and have been prescribed widely. The reports of the randomized controlled studies of phentermine had been published from 1975 to 1999, and there have been no further clinical trials on the phentermine usage since 1999. 9 Moreover, there are few reports about the effect and safety profile of phentermine in Korean. Therefore, we performed a double-blind placebo-controlled trial of phentermine in order to reaffirm the effect of phentermine on weight reduction and to verify the safety in Korean obese patients.
The study was conducted in men and women aged 20 years or older who were obese without any other documented health problems except hypertension and dyslipidemia. BMI of individual subjects were 25 kg/m 2 or higher, which is used as a cutoff point for obesity in the Asia-Pacific region. The recruitment had been done between January and February, 2005, in Seoul, and the target number of the recruitment was 80.
With respect to hypertension, those subjects, whose systolic blood pressure was controlled under 140 mmHg and diastolic pressure was controlled under 90 mmHg by taking anti-hypertensiv
Those subjects who have experienced weight change by more than 5% of baseline body weight in several months before the recruitment were excluded. Pregnant women and breast-feeding mothers were also excluded. Subjects taking any type of medication or receiving any kind of medical treatment during the previous 1 month prior to enrolment into the study were excluded, as well. Also excluded were the subjects who had any other active acute or chronic illnesses, except hypertension and dyslipidemia, subjects with the past history of malignancy or eating disorder in the last five years, subjects who had undergone a bariatric operation, and subjects who were regarded as high risk person by researchers’ judgment. Also contraindicated were the subjects with a history of significant cardiovascular disease, liver disease, renal disease, drug abuse, psychiatric conditions, or cataract. Subjects with an abnormal hematological profile, creatinine levels and/or thyroid function test were excluded, too.
All subjects were briefed on the research procedures, and a written consent for participation was obtained from each subject. The Severance Hospital Institutional Review Board approved this study.
The study had been performed between February and July, 2005. The study was a randomized, double-blind, placebo-controll
Using phentermine alternatives in cycles
During the screening period, subjects who were determined to their minds to participate in the study were measured for body weight and height, and were interviewed to confirm whether they were appropriate for the study participation. And then, they visited the researchers with an empty stomach for more accurate anthropometric measurement and screening laboratory test. According to the screening test results, final decision whether the applicant shall be included was made. Subjects who had been permitted for the study participation were randomized to treatment with phentermine HCl 37.5 mg once daily or placebo at Baseline. The ratio for phentermine and placebo was 1. 1.
After 2-week placebo run-in period, all subjects were required to visit the hospital every 4 weeks to receive behavioral therapy for obesity based on the LEARN program developed by Brownell. 12 Under the program, subjects were counseled on how to modify their behavior and diet (based on a 1500 kcal/day allowance) and how to increase their overall exercise. Compliance with the guidelines was assessed at each of these visits. Any side effects that subjects had felt during medication were to be reported to the researchers at every visit. (use our site to buy steroids online)
Body weight, waist circumference, and blood pressure were measured at the outset and at every subsequent visit. Height was determined prior to commencing study medication. Height was measured to the nearest to 0.1 cm, and weight to the nearest to 0.1 kg with the subjects wearing light clothing and with an empty stomach. Body mass index was calculated as weight in kilograms divided by the square of the height in meters. Waist size was measured to the nearest to 0.5 cm by the same person following the instructions suggested by NIH. 13 Concentration of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride in serum, fasting plasma glucose, high-sensitive CRP and uric acid levels were determined prior to commencing study medication and at endpoint.
The most valuable consideration in evaluating the efficacy is the change in body weight and waist circumference before and after the treatment in the intention-to-tre
In addition, for safety assessment, chest X-ray and ECG of each subject were taken, and thyroid stimulation hormone level was determined prior to commencing study medication, and standard laboratory tests (hematology, blood chemistry) were done prior to the commencement of study medication, and at endpoint.
Phentremine Effect in Bodybuilding
Most part of the modern birth control pills contain progesterone and estrogen hormones. Application of progesterone and estrogen is not a contraindication for use of Phentermine weight loss tablets. If use them correctly, the efficacy of birth control pills is 99%.
Note that birth control pills do not affect anorexigenic effect of Phentermine and for most women they are safe. Besides, a combined use of clomid and Phentermine improves the common state of the body and reduces the risk of colon cancer and ovarian cancer.
Combined birth control pills affect the level of estrogen in a woman’s body and prevent ovulation. To prevent unwanted pregnancy, women can use such combined birth control pills as Kariva, Aranelle, Desogen, Micronor, Ortho-Novum, Levora, Balziva, Portia, Ogestrel, Ovcon, Femcon, Junel, and Enpresse.
Recommended phentermine dosages may be different for different individuals. If your dose of phentermine is different from the amounts described, do not change without the proper approval of your doctor.
The normal phentermine dosage for adults under the age of 60 follows:
Oral dosage for capsules: Most people take 15 mg – 37.5 mg once per day, before breakfast, or approximately 1-2 hours after breakfast.
Oral dosage for tablets . Phentermine dosage is usually 15 mg – 37.5 mg once per day, before breakfast, or approximately 1-2 hours after breakfast. Also, instead of taking phentermine once a day, some physicians recommend that you take 15 mg – 37.5 mg in divided doses, 1/2 hour before meals.
Oral resin dosage form (capsules): 15mg – 30 mg, once per day, before breakfast.
Adults age 60 and over: Reduced phentermine dosages are frequently necessary for senior citizens. You should consult your physician prior to taking this medication.
Infants and children: Phentermine is NOT recommended for children under the age of 16.
Phentremine Results and Alternatives
Phentremine is a very effective appetite suppressant that can be purchased online through our weight loss center. Phentremine is formulated to reduce appetite cravings and metabolizes excess fat at a rapid pace. Using Phentremine will also burn calories while increasing energy levels. The formulation for Phentremine is the main reason for the success of our clients shedding unwanted pounds, even clients that have had difficulties in the past losing weight. The majority of our clients have benefited greatly from the treatment of Phentremine. We believe that Phentremine is the all-around best weight loss treatment on the market today, and this is why we chose Phentremine as our primary treatment for our clients. Phentremine does not have the unpleasant and dangerous side effects of prescription medications. Phentremine does not require a prescription. Phentremine is an alternative to the prescription drug phentermine.
Recommendation: Taking phentremine can help you lose weight at a rapid pace if taken consistantly with a overall diet plan. It is recommended to obtain at least a 2 month supply for maximum results. For individuals that are looking to lose 20 pounds and over it is recommended to take extra strength testosterone cypionate.The extra strength phentremine boosts metablism and burns fat quicker that regular strength.
Phentremine Before and After
We’ve all seen marketing and promotional materials for weight loss drugs, prescription and over-the-counter
Just how far do these advertisements go to show genuine results? When looking at phentermine alternatives month before and after pictures, comparisons, and claims, make sure that they come from reliable sources.
That being said, phentermine can be beneficial in your weight loss efforts. At the same time, individuals considering fat loss drugs should know that phentermine is a prescription-onl
y drug because it is classified as a Schedule IV controlled substance by the U.S. Drug Enforcement Agency.
Phentremine Side Effects
Phentermine is a potent weight loss aid that produces drastic effects on the organism, thus, it is vital to follow the doctor’s recommendations to make the treatment safe and effective. However, the medication can cause multiple common side effects, even if taken correctly. Such minor complications serve a normal reaction of the organism to a new medication and its ingredients. Among the most frequently reported common downsides are headaches, dizziness, problems sleeping, irritability, anxiety, upset stomach, diarrhea, nausea and a few other symptoms. Such reactions should fade away and fully disappear in a few days of Phentermine intake.
Misuse and overuse of the medication can cause more serious complications, including irregular, uneven heartbeat, uncontrolled muscle movements, sudden mood changes, sexual interest and ability decrease. Consult your doctor immediately after you have noticed any of such abnormalities. Seek emergency medical assistance if the following severe Phentermine side effects occur: vision changes or loss, racking headache, seizures and convulsions, slurred speech, etc. The drug may also cause serious lung and heart issues (sometimes even fatal) if not taken right. Besides, there have been cases of allergic reactions (hives, swelling, rashes, irritations, etc.) reported.